Aldose reductase: A novel therapeutic target for inflammatory pathologies

被引：148

作者：

Ramana, Kota V. ^{[1
]}

Srivastava, Satish K. ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Biochem & Mol Biol, BSB 6 638, Galveston, TX 77555 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2010年 / 42卷 / 01期

关键词：

Aldose reductase; Inflammation; Oxidative stress; NF-kappa B; Aldehydes; INHIBITION; SITE; MICE;

D O I：

10.1016/j.biocel.2009.09.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aldose reductase (AR), that catalyzes the rate limiting step of the polyol pathway of glucose metabolism, besides reducing glucose to sorbitol. reduces a number of lipid peroxidation - derived aldehydes and their glutathione conjugates. Recent studies suggest that apart from its involvement in diabetic complications, AR's catalytic activity plays a key role in a number of inflammatory diseases such as atherosclerosis, sepsis, asthma, uveitis, and colon cancer. Furthermore, AR is overexpressed in human cancers such as liver, colon, breast, cervical and ovarian. Since AR inhibitors have already undergone up to phase-iii clinical trials for diabetic complications, they could be safe anti-inflammatory drugs. Therefore the future use of AR inhibitors in down-regulating major inflammatory pathologies such as cancer and cardiovascular diseases could relieve some of the major health concerns of worldwide. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：17 / 20

页数：4

共 21 条

[1] Aldose Reductase Enzyme and its Implication to Major Health Problems of the 21st Century [J].

Alexiou, Polyxeni ;

Pegklidou, Kyriaki ;

Chatzopoulou, Maria ;

Nicolaou, Ioannis ;

Demopoulos, Vassilis J. .

CURRENT MEDICINAL CHEMISTRY, 2009, 16 (06) :734-752

[2] THE ALDO-KETO REDUCTASE SUPERFAMILY AND ITS ROLE IN DRUG METABOLISM AND DETOXIFICATION [J].

Barski, Oleg A. ;

Tipparaju, Srinivas M. ;

Bhatnagar, Aruni .

DRUG METABOLISM REVIEWS, 2008, 40 (04) :553-624

[3] Charge Density and Electrostatic Interactions of Fidarestat, an Inhibitor of Human Aldose Reductase [J].

Fournier, Bertrand ;

Bendeif, El-Eulmi ;

Guillot, Benoit ;

Podjarny, Alberto ;

Lecomte, Claude ;

Jelsch, Christian .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (31) :10929-10941

[4] LE MECANISME DE LA TRANSFORMATION DE GLUCOSE EN FRUCTOSE PAR LES VESICULES SEMINALES [J].

HERS, HG .

BIOCHIMICA ET BIOPHYSICA ACTA, 1956, 22 (01) :202-203

[5] ALDOSE REDUCTASE IN DIABETIC CATARACTS [J].

KINOSHITA, JH ;

KADOR, P ;

CATILES, M .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1981, 246 (03) :257-261

[6] Aldose reductase, still a compelling target for diabetic neuropathy [J].

Oates, Peter J. .

CURRENT DRUG TARGETS, 2008, 9 (01) :14-36

[7]

PETRASH JM, 1992, J BIOL CHEM, V267, P24833

[8] Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition [J].

Ramana, Kota V. ;

Willis, Monte S. ;

White, Michael D. ;

Horton, Jureta W. ;

DiMaio, J. Michael ;

Srivastava, Deepak ;

Bhatnagar, Aruni ;

Srivastava, Satish K. .

CIRCULATION, 2006, 114 (17) :1838-1846

[9] Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages (Publication with Expression of Concern. See vol. 294, pg. 1633, 2019) [J].

Ramana, Kota V. ;

Fadl, Amin A. ;

Tammali, Ravinder ;

Reddy, Aramati B. M. ;

Chopra, Ashok K. ;

Srivastava, Satish K. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (44) :33019-33029

[10] Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE) -: Role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth [J].

Ramana, Kota V. ;

Bhatnagar, Aruni ;

Srivastava, Sanjay ;

Yadav, Umesh C. ;

Awasthi, Sanjay ;

Awasthi, Yogesh C. ;

Srivastava, Satish K. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (26) :17652-17660

← 1 2 3 →