Estrogen-like compounds for ischemic neuroprotection

被引：59

作者：

Simpkins, JW

Yang, SH

Liu, R

Perez, E

Cai, ZY

Covey, DF

Green, PS

机构：

[1] Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX 76107 USA

[2] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

[3] Univ Washington, Sch Med, Dept Gerontol & Geriatr Med, Seattle, WA USA

来源：

STROKE | 2004年 / 35卷 / 11期

关键词：

estrogens; estrogen receptors; neuroprotection; stroke;

D O I：

10.1161/01.STR.0000143734.59507.88

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have synthesized a library of estrogen analogues, including enantiomers of estradiol and A-ring substituted estrogens. These compounds have reduced or no binding to either estrogen receptor-alpha or estrogen receptor-beta, exhibit enhanced neuroprotective activity in in vitro models, and are potent in protecting brain tissue from cerebral ischemia/reperfusion injury. These potent, nonfeminizing estrogen analogues are prime candidates for use in stroke neuroprotection.

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收藏

页码：2648 / 2651

页数：4

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