Promoting social behavior with oxytocin in high-functioning autism spectrum disorders

被引:640
作者
Andari, Elissar [1 ]
Duhamel, Jean-Rene [1 ]
Zalla, Tiziana [2 ]
Herbrecht, Evelyn [2 ]
Leboyer, Marion [2 ]
Sirigu, Angela [1 ]
机构
[1] CNRS, UMR 5229, Ctr Neurosci Cognit, F-69675 Bron, France
[2] Hop Chenevier Mondor, Dept Psychiat, INSERM, U841, F-94000 Creteil, France
关键词
cognition; neurodevelopmental disorder; recovery; Syntocinon; ASPERGER-SYNDROME; DIAGNOSTIC INTERVIEW; NEURAL CIRCUITRY; REVISED VERSION; HUMANS; INDIVIDUALS; VASOPRESSIN; MUTATIONS; COGNITION; FIXATION;
D O I
10.1073/pnas.0910249107
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Social adaptation requires specific cognitive and emotional competences. Individuals with high-functioning autism or with Asperger syndrome cannot understand or engage in social situations despite preserved intellectual abilities. Recently, it has been suggested that oxytocin, a hormone known to promote mother-infant bonds, may be implicated in the social deficit of autism. We investigated the behavioral effects of oxytocin in 13 subjects with autism. In a simulated ball game where participants interacted with fictitious partners, we found that after oxytocin inhalation, patients exhibited stronger interactions with the most socially cooperative partner and reported enhanced feelings of trust and preference. Also, during free viewing of pictures of faces, oxytocin selectively increased patients' gazing time on the socially informative region of the face, namely the eyes. Thus, under oxytocin, patients respond more strongly to others and exhibit more appropriate social behavior and affect, suggesting a therapeutic potential of oxytocin through its action on a core dimension of autism.
引用
收藏
页码:4389 / 4394
页数:6
相关论文
共 32 条
[1]  
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
[2]   The neuroscience of affiliation: Forging links between basic and clinical research on neuropeptides and social behavior [J].
Bartz, Jennifer A. ;
Hollander, Eric .
HORMONES AND BEHAVIOR, 2006, 50 (04) :518-528
[3]   Gaze fixation and the neural circuitry of face processing in autism [J].
Dalton, KM ;
Nacewicz, BM ;
Johnstone, T ;
Schaefer, HS ;
Gernsbacher, MA ;
Goldsmith, HH ;
Alexander, AL ;
Davidson, RJ .
NATURE NEUROSCIENCE, 2005, 8 (04) :519-526
[4]   Oxytocin improves "mind-reading" in humans [J].
Domes, Gregor ;
Heinrichs, Markus ;
Michel, Andre ;
Berger, Christoph ;
Herpertz, Sabine C. .
BIOLOGICAL PSYCHIATRY, 2007, 61 (06) :731-733
[5]   Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders [J].
Durand, Christelle M. ;
Betancur, Catalina ;
Boeckers, Tobias M. ;
Bockmann, Juergen ;
Chaste, Pauline ;
Fauchereau, Fabien ;
Nygren, Gudrun ;
Rastam, Maria ;
Gillberg, I. Carina ;
Anckarsater, Henrik ;
Sponheim, Eili ;
Goubran-Botros, Hany ;
Delorme, Richard ;
Chabane, Nadia ;
Mouren-Simeoni, Marie-Christine ;
de Mas, Philippe ;
Bieth, Eric ;
Roge, Bernadette ;
Heron, Delphine ;
Burglen, Lydie ;
Gillberg, Christopher ;
Leboyer, Marion ;
Bourgeron, Thomas .
NATURE GENETICS, 2007, 39 (01) :25-27
[6]   The neuroendocrine basis of social recognition [J].
Ferguson, JN ;
Young, LJ ;
Insel, TR .
FRONTIERS IN NEUROENDOCRINOLOGY, 2002, 23 (02) :200-224
[7]   Emanuel Miller lecture: Confusions and controversies about Asperger Syndrome [J].
Frith, U .
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2004, 45 (04) :672-686
[8]   The Asperger Syndrome (and high-functioning autism) -: Diagnostic Interview (ASDI):: a preliminary study of a new structured clinical interview [J].
Gillberg, C ;
Gillberg, C ;
Råstam, M ;
Wentz, E .
AUTISM, 2001, 5 (01) :57-66
[9]   Oxytocin and autistic disorder: Alterations in peptide forms [J].
Green, LA ;
Fein, D ;
Modahl, C ;
Feinstein, C ;
Waterhouse, L ;
Morris, M .
BIOLOGICAL PSYCHIATRY, 2001, 50 (08) :609-613
[10]   Oxytocin enhances the encoding of positive social memories in humans [J].
Guastella, Adam J. ;
Mitchell, Philip B. ;
Mathews, Frosso .
BIOLOGICAL PSYCHIATRY, 2008, 64 (03) :256-258