Expression of platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA in ovarian cancers

被引：26

作者：

Fujimoto, J ^{[1
]}

Ichigo, S ^{[1
]}

Sakaguchi, H ^{[1
]}

Hirose, R ^{[1
]}

Tamaya, T ^{[1
]}

机构：

[1] Gifu Univ, Sch Med, Dept Obstet & Gynecol, Gifu 500, Japan

来源：

CANCER LETTERS | 1998年 / 126卷 / 01期

关键词：

PD-ECGF; neovascularization; ovarian cancer;

D O I：

10.1016/S0304-3835(97)00537-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The potential of growth, invasion and metastasis of ovarian cancer cells associated with neovascularization, and the expression of platelet-derived endothelial growth factor (PD-ECGF) and its mRNA in ovarian cancers were determined. The relationship between their expression and histopathological types and clinical stages of ovarian cancers was also analyzed. The levels of PD-ECGF and its mRNA were higher in ovarian cancers than in normal ovaries. Furthermore. some endometrioid carcinomas and serous cystadenocarcinomas of the ovary and some ovarian cancers in stages III and IV expressed remarkably high levels of PD-ECGF and its mRNA. Therefore, in some ovarian cancers, PD-ECGF might be related to advanced stages of ovarian cancers associated with neovascularization. Published by Elsevier Science ireland Ltd.

引用

页码：83 / 88

页数：6

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