Large-scale imaging of retinal output activity

被引:25
作者
Litke, AM
Chichilnisky, EJ
Dabrowski, W
Grillo, AA
Grybos, P
Kachiguine, S
Rahman, M
Taylor, G
机构
[1] Univ Calif Santa Cruz, Santa Cruz Inst Particle Phys, Santa Cruz, CA 95064 USA
[2] Salk Inst Biol Studies, La Jolla, CA 92037 USA
[3] Stanislaw Staszic Univ Min & Met, Fac Phys & Nucl Tech, PL-30059 Krakow, Poland
[4] Univ Glasgow, Glasgow, Lanark, Scotland
关键词
multielectrode array; retina; neural processing; neural coding;
D O I
10.1016/S0168-9002(02)02049-1
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
A system is being developed to study how the retina processes, encodes and communicates information about the visual world to the brain. It will image the activity of retinal output neurons over a region of live retina approaching that used for significant neural computation in the visual cortex. A prototype system consisting of 61 microelectrodes, covering an area of 0.17 mm(2), is described, including some first results with monkey retina. The plans and status for a system with 512 microelectrodes, covering an area of 1.7 mm(2), are also given. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:298 / 307
页数:10
相关论文
共 22 条
[1]  
[Anonymous], LABVIEW SOFTW
[2]  
Berry MJ, 1998, J NEUROSCI, V18, P2200
[3]   Anticipation of moving stimuli by the retina [J].
Berry, MJ ;
Brivanlou, IH ;
Jordan, TA ;
Meister, M .
NATURE, 1999, 398 (6725) :334-338
[4]   Mechanisms of concerted firing among retinal ganglion cells [J].
Brivanlou, IH ;
Warland, DK ;
Meister, M .
NEURON, 1998, 20 (03) :527-539
[5]   Adaptation to temporal contrast in primate and salamander retina [J].
Chander, D ;
Chichilnisky, EJ .
JOURNAL OF NEUROSCIENCE, 2001, 21 (24) :9904-9916
[6]   Receptive-field microstructure of blue-yellow ganglion cells in primate retina [J].
Chichilnisky, EJ ;
Baylor, DA .
NATURE NEUROSCIENCE, 1999, 2 (10) :889-893
[7]  
Chichilnisky EJ, 2001, NETWORK-COMP NEURAL, V12, P199, DOI 10.1088/0954-898X/12/2/306
[8]   Fabrication of microelectrode arrays for neural measurements from retinal tissue [J].
Cunningham, W ;
Mathieson, K ;
McEwan, FA ;
Blue, A ;
McGeachy, R ;
McLeod, JA ;
Morris-Ellis, C ;
O'Shea, V ;
Smith, KM ;
Litke, A ;
Rahman, M .
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2001, 34 (18) :2804-2809
[9]   Mosaic arrangement of ganglion cell receptive fields in rabbit retina [J].
DeVries, SH ;
Baylor, DA .
JOURNAL OF NEUROPHYSIOLOGY, 1997, 78 (04) :2048-2060
[10]   Correlated firing in rabbit retinal ganglion cells [J].
DeVries, SH .
JOURNAL OF NEUROPHYSIOLOGY, 1999, 81 (02) :908-920