Functional expression of a mammalian odorant receptor

被引：486

作者：

Zhao, HQ

Ivic, L

Otaki, JM

Hashimoto, M

Mikoshiba, K

Firestein, S ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

[2] Yale Univ, Interdept Neurosci Program, New Haven, CT 06510 USA

[3] RIKEN, Tsukuba Life Sci Ctr, Mol Neurobiol Lab, Tsukuba, Ibaraki 305, Japan

来源：

SCIENCE | 1998年 / 279卷 / 5348期

关键词：

D O I：

10.1126/science.279.5348.237

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Candidate mammalian odorant receptors were first cloned some 6 years ago. The physiological function of these receptors in initiating transduction in olfactory receptor neurons remains to be established. Here, a recombinant adenovirus was used to drive expression of a particular receptor gene in an increased number of sensory neurons in the rat olfactory epithelium. Electrophysiological recording showed that increased expression of a single gene led to greater sensitivity to a small subset of odorants.

引用

页码：237 / 242

页数：6

共 37 条

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