False discovery control for random fields \

被引:91
作者
Pacifico, MP
Genovese, C
Verdinelli, I
Wasserman, L
机构
[1] Univ Roma La Sapienza, Dipartimento Stat Probabil & Stat Appl, I-00185 Rome, Italy
[2] Carnegie Mellon Univ, Dept Stat, Pittsburgh, PA 15213 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
false discovery rate; multiple hypothesis test; random field; scan statistic;
D O I
10.1198/0162145000001655
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
This article extends false discovery rates to random fields. for which there are uncountably many hypothesis tests. We develop a method for finding regions in the field's domain where there is a significant signal while controlling either the proportion of area or the proportion of clusters in which false rejections occur. The method produces confidence envelopes for the proportion of false discoveries as a function of the rejection threshold. From the confidence envelopes, we derive threshold procedures to control either the mean or the specified tail probabilities of the false discovery proportion. An essential ingredient of this construnction is a new algorithm to compute a confidence superset for the set of all true-null locations. We demonstrate our method with applications to scan statistics and functional neuroimaging.
引用
收藏
页码:1002 / 1014
页数:13
相关论文
共 38 条
[1]  
Adler R. J., 1981, GEOMETRY RANDOM FIEL
[2]  
ADLER R. J., 1990, I MATH STATIST LECT, V12
[3]   On excursion sets, tube formulas and maxima of random fields [J].
Adler, RJ .
ANNALS OF APPLIED PROBABILITY, 2000, 10 (01) :1-74
[4]   A critique of the use of the Kolmogorov-Smirnov (KS) statistic for the analysis of BOLD fMRI data [J].
Aguirre, GK ;
Zarahn, E ;
D'Esposito, M .
MAGNETIC RESONANCE IN MEDICINE, 1998, 39 (03) :500-505
[5]   Permutation testing made practical for functional magnetic resonance image analysis [J].
Belmonte, M ;
Yurgelun-Todd, D .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2001, 20 (03) :243-248
[6]  
Benjamini Y, 2001, ANN STAT, V29, P1165
[7]   CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].
BENJAMINI, Y ;
HOCHBERG, Y .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300
[8]  
Benjamini Y, 2003, HIERARCHICAL FDR TES
[9]   Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain [J].
Bullmore, ET ;
Suckling, J ;
Overmeyer, S ;
Rabe-Hesketh, S ;
Taylor, E ;
Brammer, MJ .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 1999, 18 (01) :32-42
[10]  
Cao J, 1999, ANN STAT, V27, P925