Vascular remodelling in chronic inflammatory periodontal disease

被引:52
作者
Chapple, CC
Kumar, RK
Hunter, N
机构
[1] Inst Dent Res, Sydney, NSW, Australia
[2] Univ Sydney, Dept Oral Biol, Sydney, NSW 2006, Australia
[3] Univ New S Wales, Sch Pathol, Kensington, NSW 2033, Australia
关键词
basic fibroblast growth factor (bFGF); immunohistochemistry; laminin; periodontitis; type IV collagen; vascular endothelial growth factor (VEGF); vascular remodelling;
D O I
10.1034/j.1600-0714.2000.291004.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Periodontitis is a chronic inflammatory disease of the highly vascularised supporting tissues of the teeth. Little is known about the vascular changes in untreated advanced periodontitis, Using confocal immunofluorescence microscopy and morphometry, we defined and quantified vascular remodelling in this lesion. In the connective tissue subjacent to the altered epithelium lining of the periodontal pocket, there was a significant increase in the numerical density of vascular profiles, primarily accounted for by vessels greater than or equal to 25 mu m in diameter. In addition, Vascular basement membranes were thickened and there was accumulation of non-vascular basement membrane remnants. We investigated the distribution of major angiogenic growth factors in periodontitis using immunohistochemistry. Basic fibroblast growth factor, although consistently associated with blood vessels, showed no regional variation in its distribution. In contrast, there was a marked regional variation in the intensity of immunostaining for vascular endothelial growth factor, with significantly reduced staining of the pocket epithelium. The changes in the vascularity of the periodontal connective tissues in untreated advanced periodontitis may be, in part, a consequence of altered expression of angiogenic activity by the epithelium, In turn, this may reflect the epithelial response to microbial flora in the microenvironment of the periodontal pocket.
引用
收藏
页码:500 / 506
页数:7
相关论文
共 28 条
[1]   VASCULAR REACTION IN PLAQUE-INDUCED GINGIVITIS - A QUANTITATIVE APPROACH [J].
BERGSTROM, J .
JOURNAL OF PERIODONTAL RESEARCH, 1992, 27 (06) :604-608
[2]   The vasculature in chronic adult periodontitis: A qualitative and quantitative study [J].
Bonakdar, MPS ;
Barber, PM ;
Newman, HN .
JOURNAL OF PERIODONTOLOGY, 1997, 68 (01) :50-58
[3]  
Booth V, 1998, J PERIODONTAL RES, V33, P491
[4]   VASCULAR PROLIFERATION AND ANGIOGENIC FACTORS IN PSORIASIS [J].
CREAMER, JD ;
BARKER, JNWN .
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1995, 20 (01) :6-9
[5]   The microbial challenge in periodontitis [J].
Darveau, RP ;
Tanner, A ;
Page, RC .
PERIODONTOLOGY 2000, 1997, 14 :12-32
[6]  
GAVIN J B, 1970, Journal of Periodontal Research, V5, P19, DOI 10.1111/j.1600-0765.1970.tb01833.x
[7]  
HAAPASALMI K, 1995, AM J PATHOL, V147, P193
[8]   BLOOD-FLOW IN HEALED AND INFLAMED PERIODONTAL TISSUES OF DOGS [J].
HOCK, JM ;
KIM, S .
JOURNAL OF PERIODONTAL RESEARCH, 1987, 22 (01) :1-5
[9]  
HOLTHOFER H, 1982, LAB INVEST, V47, P60
[10]   The codependence of angiogenesis and chronic inflammation [J].
Jackson, JR ;
Seed, MP ;
Kircher, CH ;
Willoughby, DA ;
Winkler, JD .
FASEB JOURNAL, 1997, 11 (06) :457-465