HIV-1: nature's master of disguise

被引：47

作者：

Mascola, JR

Montefiori, DC

机构：

[1] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

[2] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

来源：

NATURE MEDICINE | 2003年 / 9卷 / 04期

关键词：

D O I：

10.1038/nm0403-393

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HIV-1 readily mutates to escape the immune response, evolving in ways that allow it to persist in the host. New findings reveal that HIV-1 protects itself from antibodies by putting up a shield of constantly shifting sugar moieties. This shield may be contributing to the poor performance of candidate HIV-1 vaccines.

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收藏

页码：393 / 394

页数：2

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