PCBs and DDT in the serum of juvenile California sea lions: associations with vitamins A and E and thyroid hormones

Top-trophic predators like California sea lions bioaccumulate high levels of persistent fat-soluble pollutants that may provoke physioiogical impairments such as endocrine or vitamins A and E disruption. We measured circulating levels of polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDT) in 12 healthy juvenile California sea lions captured on Ano Nuevo Island, California, in 2002. We investigated the relationship between the contamination by PCBs and DDT and the circulating levels of vitamins A and E and thyroid hormones (thyroxine, T4 and triiodothyronine, T3). Serum concentrations of total PCBs (SigmaPCBS) and total DDT were 14 +/- 9 mg/kg and 28 +/- 19 mg/kg lipid weight, respectively. PCB toxic equivalents (SigmaPCB TEQs) were 320 +/- 170 ng/kg lipid weight. Concentrations of SigmaPCBs and SigmaPCB TEQs in serum lipids were negatively correlated (p < 0.05) with serum vitamin A and T3, potentially reflecting PCB-related toxicity. A slight but not significant negative correlation (p < 0.1) was observed between serum T4 and the levels of SigmaPCBs and SigmaPCB TEQs. Conversely, no relationship was evident between the contaminant concentrations and vitamin E (p > 0.1). As juvenile California sea lions are useful sentinels of coastal contamination, the high levels encountered in their serum is cause for concern about the ecosystem health of the area. (C) 2004 Elsevier Ltd. All rights reserved.