Mutation analysis for RUNX1, MLL-PTD, FLT3-ITD, NPM1 and NRAS in 269 patients with MDS or secondary AML

被引:118
作者
Dicker, F. [1 ]
Haferlach, C. [2 ]
Sundermann, J. [1 ]
Wendland, N. [1 ]
Weiss, T. [1 ]
Kern, W. [3 ]
Haferlach, T. [4 ]
Schnittger, S. [1 ]
机构
[1] MLL Munich Leukemia Lab, Dept Mol Genet, Munich, Germany
[2] MLL Munich Leukemia Lab, Dept Cytogenet, Munich, Germany
[3] MLL Munich Leukemia Lab, Dept Flow Cytometry, Munich, Germany
[4] MLL Munich Leukemia Lab, Dept Cytomorphol, Munich, Germany
关键词
MYELODYSPLASTIC SYNDROME; DIAGNOSIS;
D O I
10.1038/leu.2010.124
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1528 / 1532
页数:6
相关论文
共 6 条
[1]   RUNX1 gene mutation in primary myelodysplastic syndrome -: the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome [J].
Chen, Chien-Yuan ;
Lin, Liang-In ;
Tang, Jih-Luh ;
Ko, Bo-Sheng ;
Tsay, Woei ;
Chou, Wen-Chien ;
Yao, Ming ;
Wu, Shang-Ju ;
Tseng, Mei-Hsuan ;
Tien, Hwei-Fang .
BRITISH JOURNAL OF HAEMATOLOGY, 2007, 139 (03) :405-414
[2]   Cooperativity between mutations in tyrosine kinases and in hematopoietic transcription factors in AML [J].
Deguchi, K ;
Gilliland, DG .
LEUKEMIA, 2002, 16 (04) :740-744
[3]   Serial determination of FLT3 mutations in myelodysplastic syndrome patients at diagnosis, follow up or acute myeloid leukaemia transformation:: incidence and their prognostic significance [J].
Georgiou, Georgios ;
Karali, Vasiliki ;
Zouvelou, Christina ;
Kyriakou, Elias ;
Dimou, Maria ;
Chrisochoou, Stamatis ;
Greka, Paraskevi ;
Dufexis, Dimitrios ;
Vervesou, Elisavet ;
Dimitriadou, Evaggelia ;
Efthymiou, Anna ;
Petrikkos, Loizos ;
Dima, Katerina ;
Lilakos, Konstantinos ;
Panayiotidis, Panayiotis .
BRITISH JOURNAL OF HAEMATOLOGY, 2006, 134 (03) :302-306
[4]  
Germing U, 2006, HAEMATOLOGICA, V91, P1596
[5]   International scoring system for evaluating prognosis in myelodysplastic syndromes [J].
Greenberg, P ;
Cox, C ;
LeBeau, MM ;
Fenaux, P ;
Morel, P ;
Sanz, G ;
Sanz, M ;
Vallespi, T ;
Hamblin, T ;
Oscier, D ;
Ohyashiki, K ;
Toyama, K ;
Aul, C ;
Mufti, G ;
Bennett, J .
BLOOD, 1997, 89 (06) :2079-2088
[6]  
Vardiman JW., 2008, WHO CLASSIFICATION T