TRIB1 overexpression in acute myeloid leukemia

被引：29

作者：

Roethlisberger, Benno

Heizmann, Marc

Bargetzi, Mario J.

Huber, Andreas R. ^{[1
]}

机构：

[1] Kantonsspital, Ctr Lab Med, CH-5000 Aarau, Switzerland

[2] Kantonsspital, Ctr Oncol Haematol & Transfus Med, CH-5000 Aarau, Switzerland

来源：

CANCER GENETICS AND CYTOGENETICS | 2007年 / 176卷 / 01期

关键词：

D O I：

10.1016/j.cancergencyto.2007.03.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this report, an AML patient with an additional ring chromosome 8 was investigated in detail. Fluorescence in situ hybridization showed high amplification of MYC on the additional ring chromosome and signals on both chromosome 8 homologues. In addition to the amplified segment from 8q24, no additional chromosomal aberration was found by array comparative genomic hybridization. Real-time reverse-transcription polymerase chain reaction analysis revealed that MYC and TRIB1 (a gene also localized on 8q24, close to MYC) were clearly overexpressed when compared with healthy donors, acute myeloid leukemia patients without MYC amplification, chronic myeloid leukemia patients, and acute lymphatic leukemia patients. These results may indicate a key role of TRIB1 (and MYC) overexpression in the pathogenesis of a certain AML subtype. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：58 / 60

页数：3

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