Contribution of stem cells and differentiated cells to epidermal tumours

被引：243

作者：

Owens, DM ^{[1
]}

Watt, FM ^{[1
]}

机构：

[1] Canc Res UK, London Res Inst, Keratinocyte Lab, London WC2A 3PX, England

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1038/nrc1096

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The outer covering of the skin-the epidermis-is subject to sustained environmental assaults. As a result, many cells acquire potentially oncogenic mutations. Most cells are lost through differentiation, and only long-term epidermal residents, such as stem cells, accumulate the number of genetic hits that are necessary for tumour development. So, what genetic and environmental factors determine whether a mutant stem cell forms a tumour and what type of tumour will develop?.

引用

页码：444 / 451

页数：8

共 97 条

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