Death and anti-death: Tumour resistance to apoptosis

被引：1652

作者：

Igney, FH ^{[1
]}

Krammer, PH ^{[1
]}

机构：

[1] German Canc Res Ctr, Tumor Immunol Program, Heidelberg, Germany

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 04期

关键词：

D O I：

10.1038/nrc776

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells often have faulty apoptotic pathways. These defects not only increase tumour mass, but also render the tumour resistant to therapy. So, what are the molecular mechanisms of tumour resistance to apoptosis and how can we use this knowledge to resensitize tumour cells to cancer therapy?.

引用

页码：277 / 288

页数：12

共 181 条

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