Death and anti-death: Tumour resistance to apoptosis

被引:1652
作者
Igney, FH [1 ]
Krammer, PH [1 ]
机构
[1] German Canc Res Ctr, Tumor Immunol Program, Heidelberg, Germany
关键词
D O I
10.1038/nrc776
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells often have faulty apoptotic pathways. These defects not only increase tumour mass, but also render the tumour resistant to therapy. So, what are the molecular mechanisms of tumour resistance to apoptosis and how can we use this knowledge to resensitize tumour cells to cancer therapy?.
引用
收藏
页码:277 / 288
页数:12
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