Distinct frequency preferences of different types of rat hippocampal neurones in response to oscillatory input currents

被引:264
作者
Pike, FG
Goddard, RS
Suckling, JM
Ganter, P
Kasthuri, N
Paulsen, O
机构
[1] Dept Physiol, Oxford OX1 3PT, England
[2] Dept Pharmacol, Oxford, England
[3] MRC, Anat Neuropharmacol Unit, Oxford, England
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2000年 / 529卷 / 01期
关键词
D O I
10.1111/j.1469-7793.2000.00205.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. Coherent network oscillations in several distinct frequency bands are seen in the hippocampus of behaving animals. To investigate how different neuronal types within this network respond to oscillatory inputs we made whole-cell current clamp recordings from three different types of neurones in the CA1. region of rat hippocampal slices: pyramidal cells, fast-spiking interneurones and horizontal interneurones, and recorded their response to sinusoidal inputs at physiologically relevant frequencies (1-100 Hz). 2. Pyramidal neurones showed firing preference Do inputs at theta frequencies (range 2-7 Hz; n = 30). They showed subthreshold resonance in the same frequency range (2-7 Hz; mean 4.1 +/- 0.4 Hz; n = 19). 3. Interneurones differed in their firing properties. Horizontal interneurones in the stratum oriens showed firing preference to inputs at theta frequencies (range 1.5-10 Hz; n = 10). These interneurones also showed resonance at low frequencies (range 1-5 Hz; mean 2.4 +/- 0.5 Hz; n = 7). In contrast, fast-spiking interneurones with cell bodies in the pyramidal cell layer fired preferentially at input frequencies in the gamma band (range 30-50 Hz; n = 10/12). These interneurones showed resonance at beta-gamma frequencies (10-50 Hz; mean 26 +/- 5 Hz; n = 7/8). 4. Thus, in the hippocampus, different types of neurones have distinct frequency preferences. Therefore, in the CA1 layer of the hippocampal network, a compound oscillatory input may be segregated into distinct frequency components which are processed locally by distinct types of neurones.
引用
收藏
页码:205 / 213
页数:9
相关论文
共 32 条
[1]   Facilitating pyramid to horizontal oriens-alveus interneurone inputs: dual intracellular recordings in slices of rat hippocampus [J].
Ali, AB ;
Thomson, AM .
JOURNAL OF PHYSIOLOGY-LONDON, 1998, 507 (01) :185-199
[2]   Electroencephalogram in humans [J].
Berger, H .
ARCHIV FUR PSYCHIATRIE UND NERVENKRANKHEITEN, 1929, 87 :527-570
[3]   SYNAPTIC INPUT OF HORIZONTAL INTERNEURONS IN STRATUM-ORIENS OF THE HIPPOCAMPAL CA1 SUBFIELD - STRUCTURAL BASIS OF FEEDBACK ACTIVATION [J].
BLASCOIBANEZ, JM ;
FREUND, TF .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1995, 7 (10) :2170-2180
[4]  
BRAGIN A, 1995, J NEUROSCI, V15, P47
[5]   DIVERSE SOURCES OF HIPPOCAMPAL UNITARY INHIBITORY POSTSYNAPTIC POTENTIALS AND THE NUMBER OF SYNAPTIC RELEASE SITES [J].
BUHL, EH ;
HALASY, K ;
SOMOGYI, P .
NATURE, 1994, 368 (6474) :823-828
[6]   CELLULAR BASES OF HIPPOCAMPAL EEG IN THE BEHAVING RAT [J].
BUZSAKI, G ;
LEUNG, LWS ;
VANDERWOLF, CH .
BRAIN RESEARCH REVIEWS, 1983, 6 (02) :139-171
[7]   Intrinsic theta-frequency membrane potential oscillations in hippocampal CA1 interneurons of stratum lacunosum-moleculare [J].
Chapman, CA ;
Lacaille, JC .
JOURNAL OF NEUROPHYSIOLOGY, 1999, 81 (03) :1296-1307
[8]   Activation of nicotinic acetylcholine receptors patterns network activity in the rodent hippocampus [J].
Cobb, SR ;
Bulters, DO ;
Suchak, S ;
Riedel, G ;
Morris, RGM ;
Davies, CH .
JOURNAL OF PHYSIOLOGY-LONDON, 1999, 518 (01) :131-140
[9]  
COBB SR, 1995, NATURE, V394, P186
[10]  
Fellous JM, 2000, HIPPOCAMPUS, V10, P187, DOI 10.1002/(SICI)1098-1063(2000)10:2<187::AID-HIPO8>3.0.CO