TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein-Barr virus

被引：46

作者：

Lautscham, G

Rickinson, A

Blake, N

机构：

[1] Univ Liverpool, Dept Med Microbiol, Liverpool L69 3GA, Merseyside, England

[2] Univ Birmingham, Canc Res UK, Inst Canc Studies, Birmingham B15 2TT, W Midlands, England

[3] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

来源：

MICROBES AND INFECTION | 2003年 / 5卷 / 04期

基金：

英国医学研究理事会;

关键词：

Epstein-Barr virus (EBV); MHC class I processing; TAP independence; hydrophobicity;

D O I：

10.1016/S1286-4579(03)00031-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

For recognition by CD8(+) lymphocytes, peptides derived from cytosolically processed antigen need to access MHC class I molecules en route to the target cell surface. This normally requires peptide transport into the endoplasmic reticulum via the transporter associated with antigen presentation (TAP) complex. However, as recent work with Epstein-Barr virus illustrates, TAP-independent presentation pathways also exist and are growing in number. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：291 / 299

页数：9

共 53 条

[1] TAP1-INDEPENDENT LOADING OF CLASS-I MOLECULES BY EXOGENOUS VIRAL-PROTEINS
BACHMANN, MF
OXENIUS, A
PIRCHER, H
HENGARTNER, H
ASHTONRICHARDT, PA
TONEGAWA, S
ZINKERNAGEL, RM
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (06) : 1739 - 1743
[2] Dendritic cells and the control of immunity
Banchereau, J
Steinman, RM
[J]. NATURE, 1998, 392 (6673) : 245 - 252
[3] Human CD8+ T cell responses to EBV EBNA1:: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing
Blake, N
Lee, S
Redchenko, I
Thomas, W
Steven, N
Leese, A
Steigerwald-Mullen, P
Kurilla, MG
Frappier, L
Rickinson, A
[J]. IMMUNITY, 1997, 7 (06) : 791 - 802
[4] The importance of exogenous antigen in priming the human CD8+ T cell response:: Lessons from the EBV nuclear antigen EBNA1
Blake, N
Haigh, T
Shaka'a, G
Croom-Carter, D
Rickinson, A
[J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (12) : 7078 - 7087
[5] BRAUD VM, 1997, CURR BIOL, V8, P1
[6] Intracellular delivery of a cytolytic T-lymphocyte epitope peptide by pertussis toxin to major histocompatibility complex class I without involvement of the cytosolic class I antigen processing pathway
Carbonetti, NH
Irish, TJ
Chen, CH
O'Connell, CB
Hadley, GA
McNamara, U
Tuskan, RG
Lewis, GK
[J]. INFECTION AND IMMUNITY, 1999, 67 (02) : 602 - 607
[7] Asymptomatic deficiency in the peptide transporter associated to antigen processing (TAP)
De la Salle, H
Saulquin, X
Mansour, I
Klaymé, S
Fricker, D
Zimmer, J
Cazenave, JP
Hanau, D
Bonneville, M
Houssaint, E
Lefranc, G
Naman, R
[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2002, 128 (03) : 525 - 531
[8] delaSalle H, 1997, J IMMUNOL, V158, P4555
[9] TAP deficiency syndrome
Gadola, SD
Moins-Teisserenc, HT
Trowsdale, J
Gross, WL
Cerundolo, V
[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2000, 121 (02) : 173 - 178
[10] Major histocompatibility complex class I viral antigen processing in the secretory pathway defined by the trans-Golgi network protease furin
Gil-Torregrosa, BC
Castaño, AR
Del Val, M
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (06) : 1105 - 1116

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