Regulation of drug transporters during infections and inflammation

被引：122

作者：

Petrovic, Vanja ^{[1
]}

Teng, Shirley

Piquette-Miller, Micheline

机构：

[1] Univ Toronto, Dept Pharmaceut Sci, Toronto, ON, Canada

[2] Univ Toronto, Fac Pharm, Toronto, ON, Canada

来源：

MOLECULAR INTERVENTIONS | 2007年 / 7卷 / 02期

关键词：

D O I：

10.1124/mi.7.2.10

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammation-induced changes in the pharmacokinetics and dynamics of numerous drugs have been reported. Altered drug disposition during inflammatory disease has traditionally been ascribed primarily to changes in drug metabolism and protein binding. Emerging evidence within the last decade, however, has demonstrated that the inflammatory response affects the expression of several important drug transporters and these changes significantly impact the disposition and activity of drug substrates.

引用

页码：99 / 111

页数：13

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