Defective B cell response to TLR9 ligand (CpG-ODN), Streptococcus pneumoniae and Haemophilus influenzae extracts in common variable immunodeficiency patients

被引：22

作者：

Escobar, Danilo ^{[1
]}

Pons, Jaime ^{[1
]}

Clemente, Antonio ^{[1
]}

Iglesias, Julio ^{[1
]}

Regueiro, Veronica ^{[2
,3
]}

Bengoechea, Jose A. ^{[2
,3
]}

Matamoros, Nuria ^{[1
]}

Ferrer, Joana M. ^{[1
]}

机构：

[1] Hosp Son Dureta, IUNICS, Serv Immunol, Palma de Mallorca 07014, Spain

[2] Fundacio Caubet CIMERA, CIBERES, Bunyola, Spain

[3] Fundacio Caubet CIMERA, Program Infect & Immun, Bunyola, Spain

来源：

CELLULAR IMMUNOLOGY | 2010年 / 262卷 / 02期

关键词：

B cells; Toll-like receptors; Common variable immunodeficiency; TOLL-LIKE RECEPTORS; PNEUMOCOCCAL INFECTION; ACQUIRED-IMMUNITY; IN-VIVO; ACTIVATION; EXPRESSION; DISEASE; MEMORY; RECOGNITION; MICE;

D O I：

10.1016/j.cellimm.2010.01.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinaemia and antibody deficiency to both T dependent and independent antigens. Patients suffer from recurrent sinopulmonary infections mostly caused by Streptococcus pneumoniae and Haemophilus influenzae, but also gastrointestinal or autoimmune symptoms. Their response to vaccination is poor or absent. In this study we investigated B cell activation induced by the TLR9 specific ligand (CpG-ODN) and bacterial extracts from S. pneumoniae and H. influenzae known to stimulate several TLR. We found that B cells from CVID patients express lower levels of CD86 after stimulation with CpG-ODN, S. pneumoniae and H. influenzae extracts in combination with anti-IgM antibody and also display a lower proliferative index when stimulated with bacterial extracts. Our results point to a broad TLR signalling defect in B lymphocytes from CVID patients that may be related to the hypogammaglobulinaemia and poor response to vaccination characteristic of these patients. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：105 / 111

页数：7

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