Quantitative trait loci affecting prion incubation time in mice

被引：103

作者：

Stephenson, DA

Chiotti, K

Ebeling, C

Groth, D

DeArmond, SJ

Prusiner, SB

Carlson, GA

机构：

[1] McLaughlin Res Inst, Great Falls, MT 59405 USA

[2] Associate Stowers Inst Med Res, Kansas City, MO 64110 USA

[3] Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

来源：

GENOMICS | 2000年 / 69卷 / 01期

关键词：

D O I：

10.1006/geno.2000.6320

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Although the gene encoding prion protein (PrP) is the major determinant of susceptibility to prion disease, other genes also affect prion incubation time in mice and may be involved in prion replication. Scrapie incubation time was analyzed as a quantitative trait using crosses between SJL/J and CAST/Ei mice; these mouse strains encode identical PrP molecules but have different incubation periods. Our analysis revealed loci on Chromosomes 9 and 11 that affect prion susceptibility. (C) 2000 Academic Press.

引用

页码：47 / 53

页数：7

共 45 条

[1]

[Anonymous], 1998, Genetics and Analysis of Quantitative Traits (Sinauer)

[2] Characterisation of two promoters for prion protein (PrP) gene expression in neuronal cells [J].