On the total synthesis of (S)-methanophenazine and the formal synthesis of (R)-methanophenazine from a common precursor

被引：12

作者：

Beifuss, U ^{[1
]}

Tietze, M ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ Chem, D-37077 Gottingen, Germany

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 50期

关键词：

electron transfer; natural products; nitrogen heterocycles; phenazines; terpenoids;

D O I：

10.1016/S0040-4039(00)01669-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methanophenazine is a new cofactor from methanogenic archaea. (S)-Methanophenazine has been synthesized from three building blocks, i.e. 2-hydroxy-phenazine, ethyl (R)-3-methylglutarate and (E,E)-farnesyl acetone; a stereodivergent approach from ethyl (R)-3-methylglutarate warrants the formal synthesis of (R)-methanophenazine. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9759 / 9763

页数：5

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