Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis

被引：43

作者：

Shen, Xin

Shen, Guo-miao

Wu, Jie

Gui, Xiao-hong

Li, Xia

Mei, Jian

DeRiemer, Kathryn

Gao, Qian

机构：

[1] Shanghai Med Coll, Key Lab Med Mol Virol, Shanghai 200032, Peoples R China

[2] Inst Med Microbiol, Shanghai 200032, Peoples R China

[3] Inst Biomed Sci, Shanghai 200032, Peoples R China

[4] Fudan Univ, Shanghai 200032, Peoples R China

[5] Shanghai Municipal Ctr Dis Control & Prevent, Dept TB Control, Shanghai, Peoples R China

[6] Univ Calif Davis, Sch Med, Davis, CA 95616 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 07期

关键词：

D O I：

10.1128/AAC.01516-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis.

引用

页码：2618 / 2620

页数：3

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