Oral tolerance: Immune mechanisms and treatment of autoimmune diseases

被引：609

作者：

Weiner, HL ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 07期

关键词：

D O I：

10.1016/S0167-5699(97)01053-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Orally administered proteins induce systemic hyporesponsiveness to the fed protein. The mechanism underlying such 'oral tolerance' depends on the amount of antigen fed, with higher doses inducing deletion and anergy, and lower doses inducing regulatory cells. Orally administered autoantigens suppress many experimental autoimmune diseases, as discussed here by Howard Weiner.

引用

页码：335 / 343

页数：9

共 144 条

[1] Al-Sabbagh Ahmad M., 1997, Neurology, V48, pA421
[2] ANTIGEN-DRIVEN TISSUE-SPECIFIC SUPPRESSION FOLLOWING ORAL TOLERANCE - ORALLY-ADMINISTERED MYELIN BASIC-PROTEIN SUPPRESSES PROTEOLIPID PROTEIN-INDUCED EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN THE SJL MOUSE
ALSABBAGH, A
MILLER, A
SANTOS, LMB
WEINER, HL
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (09) : 2104 - 2109
[3] Antigen-driven peripheral immune tolerance: Suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen
AlSabbagh, A
Nelson, PA
Akselband, Y
Sobel, RA
Weiner, HL
[J]. CELLULAR IMMUNOLOGY, 1996, 171 (01) : 111 - 119
[4] AlSabbagh AM, 1996, J NEUROSCI RES, V45, P424, DOI 10.1002/(SICI)1097-4547(19960815)45:4<424::AID-JNR11>3.0.CO
[5] 2-0
[6] BAGOT M, 1995, EUR J DERMATOL, V5, P614
[7] A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis
Barnett, ML
Combitchi, D
Trentham, DE
[J]. ARTHRITIS AND RHEUMATISM, 1996, 39 (04): : 623 - 628
[8] Becker KJ, 1997, STROKE, V28, P72
[9] ORAL-ADMINISTRATION OF HUMAN INSULIN TO NOD MICE GENERATES CD4(+) T-CELLS THAT SUPPRESS ADOPTIVE TRANSFER OF DIABETES
BERGEROT, I
FABIEN, N
MAGUER, V
THIVOLET, C
[J]. JOURNAL OF AUTOIMMUNITY, 1994, 7 (05) : 655 - 663
[10] A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes
Bergerot, I
Ploix, C
Petersen, J
Moulin, V
Rask, C
Fabien, N
Lindblad, M
Mayer, A
Czerkinsky, C
Holmgren, J
Thivolet, C
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (09) : 4610 - 4614

← 1 2 3 4 5 6 7 8 9 10 →