Glucocorticoids increase in vitro and in vivo activities of antibiotics against Chlamydophila pneumoniae

被引:3
作者
Caronzolo, D [1 ]
Lucini, V [1 ]
Pannacci, M [1 ]
Grosso, S [1 ]
Colleoni, F [1 ]
Fraschini, F [1 ]
Scaglione, F [1 ]
机构
[1] Univ Milan, Dept Pharmacol Chemotherapy & Toxicol, I-20129 Milan, Italy
关键词
D O I
10.1128/AAC.48.12.4878-4881.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The in vitro and in vivo antichlamydial activities of dexamethasone and beclomethasone alone and in combination with an antibiotic were tested. In vitro, dexamethasone and beclomethasone decreased the number of inclusion-forming units versus the control number (P < 0.001). The combination of glucocorticoids with azithromycin, telithromycin, or levofloxacin was more active than antibiotics used alone (P < 0.001). The combination, tested in a murine Chlamydophila pneumoniae infection model, produced similar results.
引用
收藏
页码:4878 / 4881
页数:4
相关论文
共 17 条
[1]   Anti-inflammatory actions of glucocorticoids: molecular mechanisms [J].
Barnes, PJ .
CLINICAL SCIENCE, 1998, 94 (06) :557-572
[2]  
BLANCK PN, 2000, EUR RESPIR J, V15, P254
[3]   Chlamydia pneumoniae and asthma [J].
Cook, PJ ;
Davies, P ;
Tunnicliffe, W ;
Ayres, JG ;
Honeybourne, D ;
Wise, R .
THORAX, 1998, 53 (04) :254-259
[4]   Chlamydia pneumoniae IgG titres and coronary heart disease:: prospective study and meta-analysis [J].
Danesh, J ;
Whincup, P ;
Walker, M ;
Lennon, L ;
Thomson, A ;
Appleby, P ;
Wong, YK ;
Bernardes-Silva, M ;
Ward, M .
BRITISH MEDICAL JOURNAL, 2000, 321 (7255) :208-212
[5]   Chlamydia pneumoniae activates IKK/IκB-mediated signaling, which is inhibited by 4-HNE and following primary exposure [J].
Donath, B ;
Fischer, C ;
Page, S ;
Prebeck, S ;
Jilg, N ;
Weber, M ;
da Costa, C ;
Neumeier, D ;
Miethke, T ;
Brand, K .
ATHEROSCLEROSIS, 2002, 165 (01) :79-88
[6]   Distinct actions of prednisolone and dexamethasone towards osteocalcin and eosinophilic cationic protein in assumed clinically equivalent doses: a study in healthy men [J].
Dubois, EFL ;
Derks, MGM ;
Zwinderman, AH ;
Dekhuijzen, PNR ;
Von Boxtel, CJ ;
Schweitzer, DH .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 58 (11) :733-737
[7]   Characterization of antiapoptotic activities of Chlamydia pneumoniae in human cells [J].
Fischer, SF ;
Schwarz, C ;
Vier, J ;
Häcker, G .
INFECTION AND IMMUNITY, 2001, 69 (11) :7121-7129
[8]  
Gieffers J, 2001, CIRCULATION, V103, P351
[9]   EVIDENCE THAT CHLAMYDIA-PNEUMONIAE CAUSES PNEUMONIA AND BRONCHITIS [J].
GRAYSTON, JT ;
ALDOUS, MB ;
EASTON, A ;
WANG, SP ;
KUO, CC ;
CAMPBELL, LA ;
ALTMAN, J .
JOURNAL OF INFECTIOUS DISEASES, 1993, 168 (05) :1231-1235
[10]   PERSISTENT INFECTION WITH CHLAMYDIA-PNEUMONIAE FOLLOWING ACUTE RESPIRATORY ILLNESS [J].
HAMMERSCHLAG, MR ;
CHIRGWIN, K ;
ROBLIN, PM ;
GELLING, M ;
DUMORNAY, W ;
MANDEL, L ;
SMITH, P ;
SCHACHTER, J .
CLINICAL INFECTIOUS DISEASES, 1992, 14 (01) :178-182