Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models

被引：37

作者：

Dressing, Gwen E. ^{[1
]}

Hagan, Christy R. ^{[1
]}

Knutson, Todd P. ^{[1
]}

Daniel, Andrea R. ^{[1
]}

Lange, Carol A. ^{[1
]}

机构：

[1] Univ Minnesota, Mason Canc Ctr, Dept Med & Pharmacol, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA

来源：

ENDOCRINE-RELATED CANCER | 2009年 / 16卷 / 02期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR RECEPTOR; STEROID-HORMONE RECEPTORS; HUMAN ESTROGEN-RECEPTOR; CYCLIN D1; ANDROGEN RECEPTOR; GENE-EXPRESSION; CROSS-TALK; TRANSCRIPTIONAL ACTIVATION; DOWN-REGULATION; CO-REPRESSOR;

D O I：

10.1677/ERC-08-0281

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Progesterone receptors (PR), members of the nuclear receptor superfamily, function as ligand-activated transcription factors and initiators of c-Src kinase and mitogen-activated protein kinase signaling. Bidirectional cross-talk between PR and mitogenic protein kinases results in changes in PR post-translational modification, leading to alterations in PR transcriptional activity and promoter selectivity. PR-induced rapid activation of cytoplasmic protein kinases insures precise regulatory input to downstream cellular processes that are dependent upon nuclear PR, such as cell-cycle progression, and pro-survival signaling. Here, we review interactions between PR and mitogenic protein kinases and discuss the consequences of specific post-translational modifications on PR action in breast cancer cell-line models

引用

收藏

页码：351 / 361

页数：11

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