Lactate concentrations distinguish between nucleoside neuropathy and HIV neuropathy

被引：30

作者：

Brew, BJ ^{[1
]}

Tisch, S

Law, M

机构：

[1] St Vincents Hosp, Dept Neurol, Darlinghurst, NSW 2010, Australia

[2] St Vincents Hosp, Dept HIV Med, Darlinghurst, NSW 2010, Australia

[3] Natl Ctr HIV Epidemiol & Clin Res, Darlinghurst, NSW 2010, Australia

来源：

AIDS | 2003年 / 17卷 / 07期

关键词：

D O I：

10.1097/00002030-200305020-00024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We prospectively assessed serum lactate and plasma HIV viral load in 20 patients with stavudine-related nucleoside neuropathy, 10 with HIV-related distal sensory polyneuropathy (DSPN), 20 receiving stavudine but without neuropathy and 23 not receiving stavudine and without neuropathy. Raised serum lactate levels discriminated between stavudine nucleoside neuropathy and DSPN with 90% sensitivity and 90% specificity (P=0.001). DSPN occurred despite an undetectable viral load, making it, a poor discriminator.

引用

页码：1094 / 1096

页数：3

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