Operationalizing mild cognitive impairment criteria in small vessel disease: the VMCI-Tuscany Study

被引：32

作者：

Salvadori, Emilia ^{[1
]}

Poggesi, Anna ^{[1
]}

Valenti, Raffaella ^{[1
]}

Pracucci, Giovanni ^{[1
]}

Pescini, Francesca ^{[2
,3
]}

Pasi, Marco ^{[1
]}

Nannucci, Serena ^{[1
]}

Marini, Sandro ^{[1
]}

Del Bene, Alessandra ^{[1
]}

Ciolli, Laura ^{[1
]}

Ginestroni, Andrea ^{[4
]}

Diciotti, Stefano ^{[5
]}

Orlandi, Giovanni ^{[6
]}

Di Donato, Ilaria ^{[7
]}

De Stefano, Nicola ^{[7
]}

Cosottini, Mirco ^{[8
]}

Chiti, Alberto ^{[4
]}

Federico, Antonio ^{[7
]}

Dotti, Maria Teresa ^{[7
]}

Bonuccelli, Ubaldo ^{[4
]}

Inzitari, Domenico ^{[1
]}

Pantoni, Leonardo ^{[1
,2
,3
]}

机构：

[1] Univ Florence, NEUROFARBA Dept, Neurosci Sect, Florence, Italy

[2] Univ Careggi, Azienda Osped, Stroke Unit, Florence, Italy

[3] Univ Careggi, Azienda Osped, Neurol, Florence, Italy

[4] Univ Florence, Mario Serio Dept Expt & Clin Biomed Sci, Florence, Italy

[5] Univ Bologna, Dept Elect Elect & Informat Engn Guglielmo Marcon, Cesena, Italy

[6] Univ Pisa, Dept Neurosci, Pisa, Italy

[7] Univ Siena, Dept Med Surg & Neurosci, Via Laterina 8, I-53100 Siena, Italy

[8] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Pisa, Italy

来源：

ALZHEIMERS & DEMENTIA | 2016年 / 12卷 / 04期

关键词：

Cerebrovascular disease; Vascular dementia; Mild cognitive impairment; Neuropsychology; Cognitive aging; ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; NORMATIVE VALUES; SUBTYPES; RELIABILITY; DISORDERS; ATROPHY; MRI;

D O I：

10.1016/j.jalz.2015.02.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Introduction: Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile. Methods: In a sample of cerebral small vessel disease (SVD) patients, we assessed MCI subtypes distributions according to different operationalization of Winblad criteria and compared the neuroimaging features of single versus multidomain MCI. We applied three MCI diagnostic scenarios in which the cutoffs for objective impairment and the number of considered neuropsychological tests varied. Results: Passing from a liberal to more conservative diagnostic scenarios, of 153 patients, 5% were no longer classified as MCI, amnestic multidomain frequency decreased, and nonamnestic single domain increased. Considering neuroimaging features, severe medial temporal lobe atrophy was more frequent in multidomain compared with single domain. Discussion: Operationalizing MCI criteria changes the relative frequency of MCI subtypes. Nonamnestic single domain MCI may be a previously nonrecognized type of MCI associated with SVD. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：407 / 418

页数：12

共 39 条

[1]

Twenty years after Spinnler and Tognoni:: new instruments in the Italian neuropsychologist's toolbox [J].