Insulin reverses bupivacaine-induced cardiac depression in dogs

被引:32
作者
Cho, HS
Lee, JJ
Chung, IS
Shin, BS
Kim, JA
Lee, KH
机构
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Anesthesiol, Seoul, South Korea
[2] Seoul Natl Univ, Coll Med, Seoul, South Korea
关键词
D O I
10.1097/00000539-200011000-00010
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We tested the hypothesis that an insulin infusion would effectively treat bupivacaine-induced cardiac depression in dogs. In 24 mongrel dogs anesthetized with pentobarbital (5 mg . kg(-1) . h(-1), IV), 0.5% bupivacaine was administrated at a rate of 0.5 mg . kg(-1) . min(-1) until the mixed venous oxygen saturation decreased to 60% or less. The bupivacaine infusion induced a decrease in mean arterial pressure, cardiac output, and heart rate. The dogs were randomly assigned to one of four groups after the end of bupivacaine infusion The Control (C, n = 6) and Glucose (G, n = 6) groups received an IV infusion of normal saline (2 mL/kg) and glucose (2 mL/kg of 50% dextrose in water) for 15 min, respectively. The Insulin-Glucose (IG, n = 6) group received an IV bolus of regular insulin (1 U/kg), plus a glucose infusion (2 mL/kg of 50% dextrose in water) for 15 min. The Insulin-Glucose-Potassium (IGK, n = 6) group received the same dose of insulin and glucose as the IG group, plus potassium (1-3 mEq . kg(-1) . h(-1)). Mean arterial pressure, cardiac output, heart rate, and mixed venous oxygen saturation recovered toward baseline level more rapidly in the IG and IGK groups than in the C group (within 5 min versus more than 20 min). These results suggest that the infusion of insulin and glucose might reverse bupivacaine-induced cardiac depression in dogs.
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页码:1096 / 1102
页数:7
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