Adjuvant activity of a nontoxic mutant of Escherichia coli heat-labile enterotoxin on systemic and mucosal immune responses elicited against a heterologous antigen carried by a live Salmonella enterica serovar typhimurium vaccine strain

被引：24

作者：

Guillobel, HCR

Carinhanha, JI

Cárdenas, L

Clements, JD

de Almeida, DF

Ferreira, LCS

机构：

[1] Univ Fed Rio de Janeiro, CCS, Inst Biofis Carlos Chagas Filho, Lab Fisiol Celular, BR-21941590 Rio De Janeiro, Brazil

[2] Univ Estado Rio de Janeiro, Inst Biol, Dept Biofis & Biometria, BR-20551030 Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, CCS, Inst Biol, Dept Genet, BR-21944970 Rio De Janeiro, Brazil

[4] Tulane Univ, Med Ctr, Dept Microbiol & Immunol, Sch Med, New Orleans, LA 70112 USA

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 07期

关键词：

D O I：

10.1128/IAI.68.7.4349-4353.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic and mucosal antibody responses against both the major subunit of colonization factor antigen I (CFA/I) of enterotoxigenic Escherichia coli (ETEC) and the somatic lipopolysaccharide expressed by recombinant bivalent Salmonella vaccine strains were significantly enhanced by coadministration of a detoxified derivative with preserved adjuvant effects of the ETEC heat-labile toxin, LT(R192G). The results further support the adjuvant effects of LT(R192G) and represent a simple alternative to improve responses against passenger antigens expressed by orally delivered Salmonella vaccine strains.

引用

页码：4349 / 4353

页数：5

共 34 条

[1]

BUHLER T, 1991, INFECT IMMUN, V59, P3876

[2] INFLUENCE OF STRAIN VIABILITY AND ANTIGEN DOSE ON THE USE OF ATTENUATED MUTANTS OF SALMONELLA AS VACCINE CARRIERS [J].

CARDENAS, L ;

DASGUPTA, U ;

CLEMENTS, JD .

VACCINE, 1994, 12 (09) :833-840

[3] LT(R192G), a non-toxic mutant of the heat-labile enterotoxin of Escherichia coli, elicits enhanced humoral and cellular immune responses associated with protection against lethal oral challenge with Salmonella spp. [J].

Chong, C ;

Friberg, M ;

Clements, JD .

VACCINE, 1998, 16 (07) :732-740

[4]

Clements, 1993, VACCINE RES, V2, P1

[5] ADJUVANT ACTIVITY OF ESCHERICHIA-COLI HEAT-LABILE ENTERO-TOXIN AND EFFECT ON THE INDUCTION OF ORAL TOLERANCE IN MICE TO UNRELATED PROTEIN ANTIGENS [J].

CLEMENTS, JD ;

HARTZOG, NM ;

LYON, FL .

VACCINE, 1988, 6 (03) :269-277

[6] Levels of expression and immunogenicity of attenuated Salmonella enterica serovar typhimurium strains expressing Escherichia coli mutant heat-labile enterotoxin [J].

Covone, MG ;

Brocchi, M ;

Palla, E ;

da Silveira, WD ;

Rappuoli, R ;

Galeotti, CL .

INFECTION AND IMMUNITY, 1998, 66 (01) :224-231

[7] DISSOCIATION OF ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN ADJUVANTICITY FROM ADP-RIBOSYLTRANSFERASE ACTIVITY [J].

DICKINSON, BL ;

CLEMENTS, JD .

INFECTION AND IMMUNITY, 1995, 63 (05) :1617-1623

[8]

Dickinson Bonny L., 1996, P73, DOI 10.1016/B978-012410580-5/50006-6

[9]

Doggett Teresa A., 1996, P105, DOI 10.1016/B978-012410580-5/50008-X

[10] MUTANTS OF ESCHERICHIA-COLI HEAT-LABILE TOXIN LACKING ADP-RIBOSYLTRANSFERASE ACTIVITY ACT AS NONTOXIC, MUCOSAL ADJUVANTS [J].

DOUCE, G ;

TURCOTTE, C ;

CROPLEY, I ;

ROBERTS, M ;

PIZZA, M ;

DOMENGHINI, M ;

RAPPUOLI, R ;

DOUGAN, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) :1644-1648

← 1 2 3 4 →