Body traffic: Ecology, genetics, and immunity in inflammatory bowel disease

被引：32

作者：

Braun, Jonathan ^{[1
]}

Wei, Bo ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2007年 / 2卷

关键词：

ulcerative colitis; Crohns disease; microbiology; mucosal immunology; immunoregulation; mucosal barrier; mucus; disease biomarkers;

D O I：

10.1146/annurev.pathol.1.110304.100128

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The abundant bacteria and other microbial residents of the human intestine play important roles in nutrient absorption, energy metabolism, and defense against microbial pathogens. The mutually beneficial relationship of host and commensal microbiota represents an ancient and major coevolution in composition and mutual regulation of the human mucosa and the resident microbial community. Inflammatory bowel disease (IBD) is a set of chronic, relapsing inflammatory intestinal diseases in which rules of normal host-microbial interaction have been violated. This review considers the components of this host-microbial mutualism and the ways in which it is undermined by pathogenic microbial traits and by host immune and epithelial functions that confer to them susceptibility in patients with IBD. Recent advances in understanding the genetics of IBD and the immunology of host-microbial interaction are opening new strategies for treatments that target host susceptibility, candidate microbial pathogens, and intestinal ecology.

引用

页码：401 / 429

页数：29

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