The development of microprocessor-based electrocardiographs (ECG) started at the beginning of the 1980s and have expanded through the years. The ECGs are used in various clinical settings, including intensive care wards and emergency units, that prove the validity of the scientific investigations and the efficiency of their hardware and software implementation in acquisition, preprocessing, parameter measurement, and recording of ECGs. The powerful interference elimination and drift suppression procedures developed considerably reduce requirements for high common mode rejection ratio, shielded cables, careful skin preparation, and special electrodes gels.