Role of the MAPK cascade in mammalian germ cells

被引：83

作者：

Sun, QY

Breitbart, H

Schatten, H

机构：

[1] Univ Missouri, Coll Vet Med, Dept Vet Pathobiol, Columbia, MO 65211 USA

[2] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100080, Peoples R China

[3] Bar Ilan Univ, Fac Life Sci, IL-52900 Ramat Gan, Israel

来源：

REPRODUCTION FERTILITY AND DEVELOPMENT | 1999年 / 11卷 / 7-8期

关键词：

fertilization; meiosis; MOS; oocyte maturation; protein kinase C (PKC);

D O I：

10.1071/RD00014

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mitogen-activated protein kinase (MAPK) cascade is one of the most important of the intracellular signaling pathways that play a crucial role in cell proliferation, cell differentiation and cell cycle regulation. Since the first report in 1993 of MAPK's involvement in the functional regulation of mammalian oocytes, much work has been done on the role of the MAPK cascade in germ cells in different species of mammals. This review describes the possible involvement of the MOS/MEK/MAPK/RSK cascade in spermatogenesis, sperm function, oocyte meiotic re-initiation, spindle assembly, metaphase II arrest, pronuclear formation and the entry of first mitosis, as well as the cross-talk of this cascade to maturation-promoting factor (MPF) and other signal molecules in mammals.

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页码：443 / 450

页数：8

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