C-C bond formation and cleavage in radical enzymes, a theoretical perspective

被引：46

作者：

Himo, F ^{[1
]}

机构：

[1] ALBANOVA, Royal Inst Technol, Dept Biotechnol, SE-10691 Stockholm, Sweden

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2005年 / 1707卷 / 01期

关键词：

density functional theory; pyruvate-formate lyase; spore photoproduct lyase; benzylsuccinate synthase; radical enzyme;

D O I：

10.1016/j.bbabio.2004.04.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantum chemical methods are today a viable tool ill the Study of enzyme catalysis. The development of new density functional techniques and the enormous advancement in computer power have made it possible to accurately describe active sites of enzymes. This review gives a brief account of the methods and models used in this field. Three specific enzymes are discussed: pyruvate-formate lyase (PFL), spore photoproduct lyase (SPL), and benzylsuccinate synthase (BSS). What these enzymes have in common is that they use radical chemistry to catalyze C-C bond formation or cleavage reactions. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：24 / 33

页数：10

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