Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans

被引：29

作者：

Castro, Elena M. Cornejo ^{[1
]}

Waak, Jens ^{[1
]}

Weber, Stephanie S. ^{[1
]}

Fiesel, Fabienne C. ^{[1
]}

Oberhettinger, Philipp ^{[2
]}

Schuetz, Monika ^{[2
]}

Autenrieth, Ingo B. ^{[2
]}

Springer, Wolfdieter ^{[1
]}

Kahle, Philipp J. ^{[1
]}

机构：

[1] Univ Tubingen, Lab Funct Neurogenet, Dept Neurodegenerat, Hertie Inst Clin Brain Res,German Ctr Neurodegene, D-72076 Tubingen, Germany

[2] Univ Clin Tubingen, Inst Med Microbiol & Hyg, D-72076 Tubingen, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2010年 / 117卷 / 05期

关键词：

Caenorhabditis elegans; DJ-1; Innate immunity; Parkinson's disease; p38(MAPK) pathway; REGULATING KINASE-1; PROTEIN STABILITY; OXIDATIVE STRESS; ALPHA-SYNUCLEIN; APOPTOSIS; EXPRESSION; MUTATIONS; SYSTEM;

D O I：

10.1007/s00702-010-0397-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

DJ-1 is a neuroprotective gene mutated in recessive Parkinson's disease (PD). In addition to direct protective functions in neurons, DJ-1 regulates neuroinflammatory signaling in primary mouse brain astrocytes. To assess the influence of DJ-1 on innate immunity signaling in vivo, we have generated djr-1 knockout Caenorhabditis elegans. When grown on pathogenic gram-negative bacteria, djr-1 (-/-) worms showed stronger phosphorylation of p38 mitogen-activated protein kinase (PMK-1) and hyper-induction of PMK-1 target genes. Thus, PD-associated DJ-1 contributes to regulation of innate immunity.

引用

收藏

页码：599 / 604

页数：6

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