Immunoregulation in TB: Observations and Implications

被引：33

作者：

Ellner, Jerrold J. ^{[1
,2
]}

机构：

[1] Boston Univ, Boston, MA 02215 USA

[2] Boston Med Ctr, Boston, MA USA

来源：

CTS-CLINICAL AND TRANSLATIONAL SCIENCE | 2010年 / 3卷 / 01期

关键词：

tuberculosis; immunoregulation; immuno-pathogenesis; TUMOR-NECROSIS-FACTOR; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; IMMUNE-RESPONSE; ADHERENT CELLS; TGF-BETA; ANTIGEN; GAMMA; APOPTOSIS; BLOOD;

D O I：

10.1111/j.1752-8062.2010.00180.x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Regulation of the immune response during active tuberculosis (TB) has been partly deciphered. In pulmonary TB there is transient systemic immunosuppression due to overexpression of transforming growth factor beta and interleukin-10. This is superimposed on a primary T-cell defect. Locally there is intense inflammation (lung, pleural fluid) with overexpression of immunosuppressive factors (bronchoalveolar lavage) and extensive apoptosis. These observations suggest that immune therapies should be aimed at neutralizing the negative regulatory factors rather than accentuating an already intense immune response. Also a partially effective vaccine carries the potential risk of exacerbating disease. Clin Trans Sci 2010; Volume 3: 23-28.

引用

收藏

页码：23 / 28

页数：6

相关论文

共 31 条

[1] Tuberculosis Is Associated with a Down-Modulatory Lung Immune Response That Impairs Th1-Type Immunity [J].

Almeida, Alexandre S. ;

Lago, Patricia M. ;

Boechat, Neio ;

Huard, Richard C. ;

Lazzarini, Luiz C. O. ;

Santos, Adalberto R. ;

Nociari, Marcelo ;

Zhu, Hongxia ;

Perez-Sweeney, Beatriz M. ;

Bang, Heejung ;

Ni, Quanhong ;

Huang, Jie ;

Gibson, Andrea L. ;

Flores, Vera C. ;

Pecanha, Lorena R. ;

Kritski, Afranio L. ;

Lapa e Silva, Jose R. ;

Ho, John L. .

JOURNAL OF IMMUNOLOGY, 2009, 183 (01) :718-731

[2] Induction of monocyte expression of tumor necrosis factor alpha by the 30-kD alpha antigen of Mycobacterium tuberculosis and synergism with fibronectin [J].

Aung, H ;

Toossi, Z ;

Wisnieski, JJ ;

Wallis, RS ;

Culp, LA ;

Phillips, NB ;

Phillips, M ;

Averill, LE ;

Daniel, TM ;

Ellner, JJ .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (05) :1261-1268

[3] PLEURAL FLUID AND PERIPHERAL-BLOOD LYMPHOCYTE FUNCTION IN TUBERCULOSIS [J].

ELLNER, JJ .

ANNALS OF INTERNAL MEDICINE, 1978, 89 (06) :932-933

[4]

ELLNER JJ, 1978, J IMMUNOL, V121, P2573

[5] Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis [J].

Guyot-Revol, V ;

Innes, JA ;

Hackforth, S ;

Hinks, T ;

Lalvani, A .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 173 (07) :803-810

[6] Depressed T-cell interferon-γ responses in pulmonary tuberculosis:: Analysis of underlying mechanisms and modulation with therapy [J].

Hirsch, CS ;

Toossi, Z ;

Othieno, C ;

Johnson, JL ;

Schwander, SK ;

Robertson, S ;

Wallis, RS ;

Edmonds, K ;

Okwera, A ;

Mugerwa, R ;

Peters, P ;

Ellner, JJ .

JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (06) :2069-2073

[7] Mechanisms of apoptosis of T-cells in human tuberculosis [J].

Hirsch, CS ;

Johnson, JL ;

Okwera, A ;

Kanost, RA ;

Wu, MD ;

Peters, P ;

Muhumuza, M ;

Mayanja-Kizza, H ;

Mugerwa, RD ;

Mugyenyi, P ;

Ellner, JJ ;

Toossi, Z .

JOURNAL OF CLINICAL IMMUNOLOGY, 2005, 25 (04) :353-364

[8] Cross-modulation by transforming growth factor beta in human tuberculosis: Suppression of antigen-driven blastogenesis and interferon gamma production [J].

Hirsch, CS ;

Hussain, R ;

Toossi, Z ;

Dawood, G ;

Shahid, F ;

Ellner, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (08) :3193-3198

[9] In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor beta [J].

Hirsch, CS ;

Ellner, JJ ;

Blinkhorn, R ;

Toossi, Z .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :3926-3931

[10] Apoptosis and T cell hyporesponsiveness in pulmonary tuberculosis [J].

Hirsch, CS ;

Toossi, Z ;

Vanham, G ;

Johnson, JL ;

Peters, P ;

Okwera, A ;

Mugerwa, R ;

Mugyenyi, P ;

Ellner, JJ .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (04) :945-953

← 1 2 3 4 →