The BRCA1 C-terminal domain: structure and function

被引：126

作者：

Huyton, T

Bates, PA

Zhang, XD

Sternberg, MJE

Freemont, PS

机构：

[1] Imperial Canc Res Fund, Biomolec Modelling Labs, London WC2A 3PX, England

[2] Univ London Imperial Coll Sci Technol & Med, Ctr Struct Biol, London SW7 2AY, England

来源：

MUTATION RESEARCH-DNA REPAIR | 2000年 / 460卷 / 3-4期

关键词：

BRCT; BRCA1; XRCC1; DNA damage repair; protein interaction module;

D O I：

10.1016/S0921-8777(00)00034-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The BRCA1 C-terminal region contains a duplicated globular domain termed BRCT that is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming home/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions with DNA strand breaks. The sequence and functional diversity of the BRCT superfamily suggests that BRCT domains are evolutionarily convenient interaction modules. (C) 2000 Published by Elsevier Science B.V.

引用

页码：319 / 332

页数：14

共 52 条

[1] BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase a
Anderson, SE
Schlegel, BP
Nakajima, T
Wolpin, ES
Parvin, JD
[J]. NATURE GENETICS, 1998, 19 (03) : 254 - 256
[2] Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein
Ayi, TC
Tsan, JT
Hwang, LY
Bowcock, AM
Baer, R
[J]. ONCOGENE, 1998, 17 (16) : 2143 - 2148
[3] BATES PA, 1999, PROTEINS, V3, P30
[4] Bork P, 1996, METHOD ENZYMOL, V266, P162
[5] A superfamily of conserved domains in DNA damage responsive cell cycle checkpoint proteins
Bork, P
Hofmann, K
Bucher, P
Neuwald, AF
Altschul, SF
Koonin, EV
[J]. FASEB JOURNAL, 1997, 11 (01) : 68 - 76
[6] Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells
Caldecott, KW
Tucker, JD
Stanker, LH
Thompson, LH
[J]. NUCLEIC ACIDS RESEARCH, 1995, 23 (23) : 4836 - 4843
[7] From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair
Callebaut, I
Mornon, JP
[J]. FEBS LETTERS, 1997, 400 (01): : 25 - 30
[8] Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair
Cappelli, E
Taylor, R
Cevasco, M
Abbondandolo, A
Caldecott, K
Frosina, G
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (38) : 23970 - 23975
[9] Transcriptional activation by BRCA1
Chapman, MS
Verma, IM
[J]. NATURE, 1996, 382 (6593) : 678 - 679
[10] Double strand break repair
Chu, G
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (39) : 24097 - 24100

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