Scintigraphic detection of multidrug resistance in cancer

被引：24

作者：

Del Vecchio, S

Ciarmiello, A

Salvatore, M

机构：

[1] Univ Naples Federico II, Dept Biomorphol & Funct Sci, I-80131 Naples, Italy

[2] CNR, Natl Res Council, I-00185 Rome, Italy

[3] Natl Canc Inst, Naples, Italy

来源：

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | 2000年 / 15卷 / 04期

关键词：

D O I：

10.1089/cbr.2000.15.327

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One of the most extensively studied mechanisms of drug resistance involves the drug efflux pump P-glycoprotein (Pgp), The availability of radiolabeled substrates of Pgp such as Tc-99m-MIBI and analogous Tc-99m-labeled agents allows the clinical assessment of Pgp function in cancer patients. The consistency of the results from different institutions and trials strongly support the clinical application of this imaging technique for individual tailoring of chemotherapeutic regimens and for designing clinical trials with Pgp modulators.

引用

页码：327 / 337

页数：11

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