Discovery of potent cyclic pseudopeptide human tachykinin NK-2 receptor antagonists

被引:17
作者
Giannotti, D [1 ]
Perrotta, E [1 ]
Di Bugno, C [1 ]
Nannicini, R [1 ]
Harmat, NJS [1 ]
Giolitti, A [1 ]
Patacchini, R [1 ]
Renzetti, AR [1 ]
Rotondaro, L [1 ]
Giuliani, S [1 ]
Altamura, M [1 ]
Maggi, CA [1 ]
机构
[1] Menarini Ric SpA, I-50131 Florence, Italy
关键词
D O I
10.1021/jm0010217
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:4041 / 4044
页数:4
相关论文
共 21 条
[1]   MEN 11420 (Nepadutant), a novel glycosylated bicyclic peptide tachykinin NK2 receptor antagonist [J].
Catalioto, RM ;
Criscuoli, M ;
Cucchi, P ;
Giachetti, A ;
Giannotti, D ;
Giuliani, S ;
Lecci, A ;
Lippi, A ;
Patacchini, R ;
Quartara, L ;
Renzetti, AR ;
Tramontana, M ;
Arcamone, F ;
Maggi, CA .
BRITISH JOURNAL OF PHARMACOLOGY, 1998, 123 (01) :81-91
[2]   EFFICIENT PREPARATION OF POLYFUNCTIONAL ALPHA-DIKETONES FROM CARBOXYLIC-ACIDS [J].
CONROW, R ;
PORTOGHESE, PS .
JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (06) :938-940
[3]   Molecular determinants of peptide and nonpeptide NK-2 receptor antagonists binding sites of the human tachykinin NK-2 receptor by site-directed mutagenesis [J].
Giolitti, A ;
Cucchi, P ;
Renzetti, AR ;
Rotondaro, L ;
Zappitelli, S ;
Maggi, CA .
NEUROPHARMACOLOGY, 2000, 39 (08) :1422-1429
[4]  
KOKOTOS G, 1992, J CHEM RES-S, P391
[5]  
Lombardi A, 1996, BIOPOLYMERS, V40, P505, DOI 10.1002/(SICI)1097-0282(1996)40:5<505::AID-BIP8>3.0.CO
[6]  
2-#
[7]   A novel rigid β-turn molecular scaffold [J].
Lombardi, A ;
D'Auria, G ;
Maglio, O ;
Nastri, F ;
Quartara, L ;
Pedone, C ;
Pavone, V .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (24) :5879-5886
[8]   TACHYKININ RECEPTORS IN THE GUINEA-PIG ISOLATED BRONCHI [J].
MAGGI, CA ;
PATACCHINI, R ;
QUARTARA, L ;
ROVERO, P ;
SANTICIOLI, P .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 197 (2-3) :167-174
[9]  
MAGGI CA, 1994, J PHARMACOL EXP THER, V271, P1489
[10]   TACHYKININ RECEPTORS AND TACHYKININ RECEPTOR ANTAGONISTS [J].
MAGGI, CA ;
PATACCHINI, R ;
ROVERO, P ;
GIACHETTI, A .
JOURNAL OF AUTONOMIC PHARMACOLOGY, 1993, 13 (01) :23-93