Antiplasmodial Triterpenoids from the Fruits of Neem, Azadirachta indica

被引：68

作者：

Chianese, Giuseppina ^{[1
]}

Yerbanga, Serge R. ^{[2
]}

Lucantoni, Leonardo ^{[2
]}

Habluetzel, Annette ^{[2
]}

Basilica, Nicoletta ^{[3
]}

Taramelli, Donatella ^{[3
]}

Fattorusso, Ernesto ^{[1
]}

Taglialatela-Scafati, Orazio ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Camerino, Scuola Sci Farmaco & Prodotti Salute, I-62032 Camerino, MC, Italy

[3] Univ Milan, Dipartimento Sanita Pubbl Microbiol Virol, I-20133 Milan, Italy

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 08期

关键词：

WEST-AFRICAN TIMBERS; PLASMODIUM-FALCIPARUM; BIOGENETIC INTEREST; MALARIA; DERIVATIVES; LIMONOIDS; EXTRACTS; GEDUNIN; SEEDS;

D O I：

10.1021/np100325q

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure antimalarial activity relationships in the limonoid class.

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页码：1448 / 1452

页数：5

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