Autosomal dominant hypophosphatemic rickets is linked to chromosome 12p13

Autosomal dominant hypophosphatemic rickets (ADHR) is an inherited disorder of isolated renal phosphate wasting, the pathogenesis of which is unknown, We performed a genome-wide linkage study in a large kindred to determine the chromosome location of the ADHR gene, Two-point LOD scores indicate that the gene is linked to the markers D12S314 [Z(<(theta)over cap>) = 3.15 at theta = 0.0], vWf [Z(<(theta)over cap>) = 5.32 at theta = 0.0], and CD4 [Z(<(theta)over cap>) = 3.53 at theta = 0.0]. Moreover, multilocus analysis indicates that the ADHR gene locus is located on chromosome 12p13 in the 18-cM interval between the flanking markers D12S100 and D12S397. These data are the first to establish a chromosomal location for the ADHR locus and to provide a framework map to further localize the gene, Such studies will permit ultimate identification of the ADHR gene and provide further insight into phosphate homeostasis.