Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1

被引：199

作者：

Kim, VN

Mitrophanous, K

Kingsman, SM

Kingsman, AJ

机构：

[1] UNIV OXFORD,DEPT BIOCHEM,OXFORD OX1 3QU,ENGLAND

[2] OXFORD BIOMEDICA LTD,MEDAWAR CTR,OXFORD OX4 4GA,ENGLAND

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 01期

关键词：

D O I：

10.1128/JVI.72.1.811-816.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The use of human immunodeficiency virus vectors for gene therapy is hampered by concern over their safety. This concern might be ameliorated, in part, if the viral accessory genes and proteins could be eliminated from the vector genomes and particles. Here we describe a minimal vector system that is capable of transducing nondividing cells and which does not contain tat, vif, vpr, vpu, and nef.

引用

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页码：811 / 816

页数：6

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