Influence of guideline adherence on outcome in a randomised controlled trial on the efficacy of methotrexate with folate supplementation in rheumatoid arthritis

被引:19
作者
Fransen, J
Laan, RFJM
van der Laar, MAFJ
Huizinga, TWJ
van Riel, PLCM
机构
[1] Univ Med Ctr Nijmegen, Dept Rheumatol, NL-6500 HB Nijmegen, Netherlands
[2] Med Spectrum Twente, Dept Rheumatol, Enschede, Netherlands
[3] Univ Leicester, Med Ctr, Leiden, Netherlands
关键词
D O I
10.1136/ard.2003.018861
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To study the influence of rheumatologists' adherence to a methotrexate guideline on efficacy and toxicity in the treatment of rheumatoid arthritis. Methods: In a 48 week randomised controlled trial of methotrexate, comparing folates with placebo, rheumatologists were advised on methotrexate dosage using a guideline reflecting daily practice. The influence of guideline non-adherence on outcome was analysed using generalised estimating equations and survival analysis. Results: In 51% of the 411 study patients the guidelines were always followed. Non-adherence resulted in lower doses of methotrexate in 25% of cases, and higher doses in 24%. The reduction in the disease activity score was significantly greater (mean -0.4; p=0.0085) in the adherent group than in the "low dose'' group; the "high dose'' group did not differ from the adherent group. Dropout caused by severe adverse events did not differ between the three groups. Conclusions: There is an indication that adherence to guidelines on methotrexate dosage may benefit patients with rheumatoid arthritis by improving disease activity without increasing toxicity. For definite proof, a randomised controlled trial comparing guideline supported dosing with usual care is needed.
引用
收藏
页码:1222 / 1226
页数:5
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