Selection and amplification of a catalyst from a dynamic combinatorial library

被引：131

作者：

Brisig, B

Sanders, JKM

Otto, S

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Basel, Dept Inorgan Chem, CH-4056 Basel, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 11期

关键词：

catalysis; combinatorial chemistry; host-guest chemistry; supramolecular chemistry; thermodynamic control;

D O I：

10.1002/anie.200390326

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amplification of the fittest: A dynamic combinatorial library (DCL) of macrocyclic disulfides in water was exposed to a transition-state analogue (TSA) for a Diels-Alder reaction. Two receptors were selected and amplified, of which one binds to the TSA more strongly than to the starting material and catalyzes the Diels-Alder reaction (see scheme).

引用

页码：1270 / 1273

页数：4