Urinary matrix metalloproteinase-8 and-9 activities in type 2 diabetic subjects: A marker of incipient diabetic nephropathy?

被引：43

作者：

van der Zijl, Nynke J. ^{[1
]}

Hanemaaijer, Land ^{[2
]}

Tushuizen, Maarten E. ^{[1
]}

Schindhelm, Roger K. ^{[3
]}

Boerop, Jeannette ^{[1
]}

Rustemeijer, Cees ^{[4
]}

Bilo, Henk J.

Verheijen, Jan H. ^{[2
]}

Diamant, Michaela ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Endocrinol, Ctr Diabet, Amsterdam, Netherlands

[2] TNO Qual Life, Leiden, Netherlands

[3] Isala Clin, Dept Clin Chem, Zwolle, Netherlands

[4] Amstelland Hosp, Dept Internal Med, Amstelveen, Netherlands

来源：

CLINICAL BIOCHEMISTRY | 2010年 / 43卷 / 7-8期

关键词：

MMP-2; MMP-8; MMP-9; Albuminuria; Type 2 diabetes mellitus; Diabetic nephropathy; GENE-EXPRESSION; RENAL-DISEASE; MICROALBUMINURIA; MMP-9; INHIBITION; COLLAGEN; ENZYMES; SERUM;

D O I：

10.1016/j.clinbiochem.2010.02.006

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Matrix metalloproteinases (MMPs) may play a pathophysiological role in the development of diabetic nephropathy (DN). We hypothesized that urinary MMP activity in patients with type 2 diabetes mellitus (T2DM) is related to a decline in renal function. We determined MMP-2, -8 and -9 activity in 24-h urine collections in relation to risk factors for ON in T2DM patients with (UA, n=27) and without albuminuria (NA, n=48) and controls (CO, n=28). MMP-8 and -9 levels were highest in UA patients (P<0.01). Of UA patients, 93% had at least one MMP increased, compared to 78% of NA patients and 46% of CO (P=0.001). Age, diabetes duration, BMI, systolic blood pressure, fasting plasma glucose, HbA1c and renal function were determinants of MMP-8 and -9 (P<0.05). In summary, MMP-8 and -9 are highest in T2DM UA patients. MMP-9, showed the strongest associations with clinical parameters related to DN. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：635 / 639

页数：5

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