Elimination of Onchocercia volvulus transmission in the Santa Rosa focus of Guatemala

被引:71
作者
Lindblade, Kim A.
Arana, Byron
Zea-Flores, Guillermo
Rizzo, Nidia
Porter, Charles H.
Dominguez, Alfredo
Cruz-Ortiz, Nancy
Unnasch, Thomas R.
Punkosdy, George A.
Richards, Jane
Sauerbrey, Mauricio
Castro, Julio
Catu, Eduard
Oliva, Orlando
Richards, Frank O., Jr.
机构
[1] Univ Valle Guatemala, Ctr Dis Control & Prevent, Reg Off Cent Amer & Panama, Ctr Estudios Salud, Guatemala City, Guatemala
[2] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Div Parasit Dis, Atlanta, GA USA
[3] Onchocerciasis Eliminat Program Amer, Guatemala City, Guatemala
[4] Univ Alabama, Div Geog Med, Birmingham, AL USA
[5] Minist Salud Publ & Asistencia Social, Guatemala City, Guatemala
[6] Emory Univ, Carter Ctr, Atlanta, GA 30322 USA
关键词
D O I
10.4269/ajtmh.2007.77.334
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
To eliminate transmission of Onchocerca volvulus, semiannual mass treatment with ivermectin (Mectizan; donated by Merck & Co) has been underwav in Guatemala since 2000. We applied the 2001 World Health Organization (WHO) elimination criteria in the Santa Rosa focus of onchocerciasis transmission in Guatemala (10,923 persons at risk). No evidence of parasite DNA was found in 2,221 Simulium ochraceum vectors (one-sided 95% confidence interval [CI], 0-0.086%), and no IgG4 antibody positives to recombinant antigen OV16 were found in a sample of 3,232 school children (95% Cl, 0-0.009%). We also found no evidence of microfilariae in the anterior segment of the eye in 363 area residents (95% Cl, 0-0.08%). Our interpretation of these data, together with historical information, suggest that transmission of O. volvulus is permanently interrupted in Santa Rosa and that ivermectin treatments there can be halted.
引用
收藏
页码:334 / 341
页数:8
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