Towards benign syntheses of bipyridines: versatile approach to supramolecular building blocks

被引：14

作者：

Cave, GWV ^{[1
]}

Raston, CL

机构：

[1] Univ Western Australia, Sch Biomed & Chem Sci, Perth, WA 6009, Australia

[2] Nottingham Trent Univ, Sch Biomed & Nat Sci, Nottingham NG11 8NS, England

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 14期

基金：

澳大利亚研究理事会; 英国工程与自然科学研究理事会;

关键词：

green chemistry; solvent free; pyridines; ketones;

D O I：

10.1016/j.tetlet.2005.02.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral and achiral bipyridines are readily accessible via a solvent-free Michael addition involving solid NaOH, followed by treatment with ammonium acetate in acetic acid, as a 'one pot' more benign protocol, affording pure products in high yield, typically > 80%. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2361 / 2363

页数：3

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