Frequency distribution of cytokine gene polymorphisms in the healthy North Indian population

被引：29

作者：

Kaur, G. ^{[1
]}

Rapthap, C. C. ^{[1
]}

Kumar, N. ^{[1
]}

Kumar, S. ^{[1
]}

Neolia, S. ^{[1
]}

Mehra, N. K. ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Transport Immunol & Immungenet, New Delhi 110029, India

来源：

TISSUE ANTIGENS | 2007年 / 69卷 / 02期

关键词：

cytokine genes; frequency; North Indians; polymorphism;

D O I：

10.1111/j.1399-0039.2006.00740.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The allelic and genotype frequencies corresponding to 22 single nucleotide polymorphisms (SNPs) in 13 cytokine genes interleukin (IL) 1-alpha (T/C -889), IL1-beta (C/T -511, T/C +3962), IL12 (C/A -1188), interferon-gamma (A/T UTR 5644), transforming growth factor-beta (C/T codon 10, G/C codon 25), tumour necrosis factor-alpha (G/A -308, G/A -238), IL2 (T/G -330, G/T +160), IL4 (T/G -1098, T/C -590, T/C -33), IL6 (G/C -174, G/A nt 565), IL10 (G/A -1082, C/T -819, C/A -592), IL1R (C/T pst11970), IL1RA (T/C mspa111100) and IL4RA (G/A 11902) were determined in 130 healthy North Indian subjects. All genomic typings were performed with polymerase chain reaction with sequence-specific assays. An analysis of the allelic and haplotype frequencies in the North Indian population showed a good fit with the Hardy-Weinberg equilibrium for most of the SNPs. The data can be used for anthropological comparisons, as well as for association studies with different diseases and for use in transplant situations involving acute and chronic rejection.

引用

页码：113 / 120

页数：8

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