Combination of P300 and CSF β-Amyloid(1-42) Assays May Provide a Potential Tool in the Early Diagnosis of Alzheimer's Disease

被引:21
作者
Papaliagkas, V. T. [1 ]
Anogianakis, G. [1 ]
Tsolaki, M. N. [2 ]
Koliakos, G. [3 ]
Kimiskidis, V. K. [2 ]
机构
[1] Aristotle Univ Thessaloniki, Fac Med, Dept Expt Physiol, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Dept Neurol 3, Papanikolaou Hosp G, Thessaloniki 54124, Greece
[3] Aristotle Univ Thessaloniki, Fac Med, Biol Chem Lab, Thessaloniki 54124, Greece
关键词
Mild cognitive impairment; Alzheimer's disease; beta-amyloid((1-42)); auditory event-related potentials; P300; latency; amplitude; MILD COGNITIVE IMPAIRMENT; EVENT-RELATED POTENTIALS; CEREBROSPINAL-FLUID TAU; CLINICAL-DIAGNOSIS; EVOKED-POTENTIALS; AMYLOID BETA-42; N200; LATENCY; PROTEIN; SUBCOMPONENTS; POPULATION;
D O I
10.2174/156720510791162421
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background/Aims. The aim of this study was to investigate the diagnostic role of CSF beta amyloid((1-42)) levels and auditory event-related potentials (AERPs) in the progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD). Methods. In fifty three MCI patients (group 1) a lumbar puncture was performed and beta amyloid((1-42)) levels were determined. Twenty patients (group 2) were re-examined after 11 months. During this period five of them progressed to AD. Neuropsychological and ERP examinations were performed in all patients at both exams. Results. Compared to MCI-stable patients, AD-converters showed significantly lower beta-amyloid((1-42)) values both for group 1 (Mann Whitney test, Z=-2.952, p=0.003; effect size r=-0.41) and group 2 (Z=-2.458, p=0.011; effect size r=-0.55). On the other hand, the patients of group 1 who converted to AD had prolonged latencies and lower amplitudes of the P300 wave compared to those of the MCI-stable patients, although the differences were not significant. Conclusions. Compared to the separate use of CSF beta-amyloid((1-42)) and AERPs, higher values of sensitivity and specificity were achieved by the combined use of beta-amyloid((1-42)) levels and P300 latencies (80% and 98%) or amplitudes (100% and 89%) in the discrimination between AD-converters and MCI-stable patients. Therefore the combination of an electrophysiological and a biological marker is potentially of high diagnostic value for the early diagnosis of AD-converters.
引用
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页码:295 / 299
页数:5
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