Claisen condensation as a facile route to an α-alkoxy-cinnamate:: Synthesis of ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

被引：17

作者：

Linderberg, MT ^{[1
]}

Moge, M ^{[1
]}

Sivadasan, S ^{[1
]}

机构：

[1] Proc R&D AstraZeneca, S-15185 Sodertalje, Sweden

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 06期

关键词：

D O I：

10.1021/op040006z

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

The title compound was prepared from p-anisaldehyde and ethyl ethoxyacetate via a racemic synthetic route: The synthesis involves a Claisen-type condensation in which the elimination was unexpectedly promoted by an excess of the ester. The process has been successfully performed on a 2000-L scale with a total yield over seven steps of 19%.

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页码：838 / 845

页数：8

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