Revisiting the role of IL-2 in autoimmunity

被引：43

作者：

Dooms, Hans ^{[1
]}

Abbas, Abut K. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 06期

关键词：

Autoimmunity; IL-2; Myasthenia gravis; Treg; REGULATORY T-CELLS; INTERLEUKIN-2; MICE; LYMPHOCYTES; INDUCTION; COMPLEXES; EXPANSION; RESPONSES; MEMORY; BETA;

D O I：

10.1002/eji.201040617

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

IL-2 was discovered as a T-cell growth factor that promoted T-cell-dependent immune responses; however, more recent studies suggest that the essential role of IL-2 is to maintain functional Treg and thus control immune responses. These results are leading to new ideas about the potential of IL-2 as a therapeutic strategy in autoimmune diseases. In this issue of the European Journal of Immunology, a study further examines the role of IL-2 in immune regulation and shows for the first time that IL-2 complexes can ameliorate autoantibody-mediated autoimmunity. This commentary examines the current findings in relation to what we already know about IL-2 complexes.

引用

页码：1538 / 1540

页数：3

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