Off-resonance experiments and contrast agents to improve magnetic resonance imaging

被引:16
作者
Bertini, I
Luchinat, C
Parigi, G
Quacquarini, G
Marzola, P
Cavagna, FM
机构
[1] Univ Florence, Dept Chem, I-50121 Florence, Italy
[2] Univ Florence, Dept Soil Sci & Plant Nutr, I-50121 Florence, Italy
[3] Bracco Ind Chim Spa, Milano Res Ctr, Milan, Italy
关键词
bovine serum albumin; contrast agent; gadolinium(III); manganese(II); MRI; NMRD; off-resonance;
D O I
10.1002/mrm.1910390119
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The effect of off-resonance irradiation on the water proton NMR signal intensity has been investigated as follows: (a) in the presence of a paramagnetic probe like manganese(II); (b) in the presence of bovine serum albumin (BSA) and two gadolinium(III) complexes, Gd-DTPA and Gd-BOPTA; (c) in the presence of cross-linked BSA and the two above-mentioned gadolinium(III) complexes, The experimental data have been rationalized on the basis of the available theoretical models, The effectiveness of the two complexes as contrast agents for MRI has been predicted, It is shown that contrast agents providing comparable longitudinal and transverse relaxation rate enhancements are those of general interest for off-resonance magnetization transfer-MRI.
引用
收藏
页码:124 / 131
页数:8
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